Protective efficacy of intranasal cold-adapted influenza A/New Caledonia/20/99 (H1N1) vaccines comprised of egg- or cell culture-derived reassortants.
Identifieur interne : 001653 ( Main/Exploration ); précédent : 001652; suivant : 001654Protective efficacy of intranasal cold-adapted influenza A/New Caledonia/20/99 (H1N1) vaccines comprised of egg- or cell culture-derived reassortants.
Auteurs : Thomas Palker [États-Unis] ; Irina Kiseleva ; Kimberly Johnston ; Qin Su ; Timothy Toner ; Christopher Szymkowiak ; Wan-Sang Kwan ; Boris Rubin ; Luba Petrukhin ; Joan Wlochowski ; Juanita Monteiro ; Nikolai Kraiouchkine ; Daniel Distefano ; Larisa Rudenko ; Alan Shaw ; Rima YouilSource :
- Virus research [ 0168-1702 ] ; 2004.
Descripteurs français
- KwdFr :
- Administration par voie nasale, Animaux, Chiens, Embryon de poulet, Furets, Glycoprotéine hémagglutinine du virus influenza (génétique), Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (immunologie), Lignée cellulaire, Liquide de lavage bronchoalvéolaire (virologie), Liquide de lavage nasal (virologie), Modèles animaux de maladie humaine, Méthode des plages virales, Protéines virales (génétique), Sialidase (génétique), Sous-type H1N1 du virus de la grippe A, Vaccination, Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (immunologie), Virus de la grippe A (croissance et développement), Virus de la grippe A (génétique), Virus de la grippe A (immunologie), Virus recombinants (croissance et développement), Virus recombinants (génétique), Virus recombinants (immunologie).
- MESH :
- administration et posologie : Vaccins antigrippaux.
- croissance et développement : Virus de la grippe A, Virus recombinants.
- génétique : Glycoprotéine hémagglutinine du virus influenza, Protéines virales, Sialidase, Virus de la grippe A, Virus recombinants.
- immunologie : Infections à Orthomyxoviridae, Vaccins antigrippaux, Virus de la grippe A, Virus recombinants.
- virologie : Liquide de lavage bronchoalvéolaire, Liquide de lavage nasal.
- Administration par voie nasale, Animaux, Chiens, Embryon de poulet, Furets, Infections à Orthomyxoviridae, Lignée cellulaire, Modèles animaux de maladie humaine, Méthode des plages virales, Sous-type H1N1 du virus de la grippe A, Vaccination.
English descriptors
- KwdEn :
- Administration, Intranasal, Animals, Bronchoalveolar Lavage Fluid (virology), Cell Line, Chick Embryo, Disease Models, Animal, Dogs, Ferrets, Hemagglutinin Glycoproteins, Influenza Virus (genetics), Influenza A Virus, H1N1 Subtype, Influenza A virus (genetics), Influenza A virus (growth & development), Influenza A virus (immunology), Influenza Vaccines (administration & dosage), Influenza Vaccines (immunology), Nasal Lavage Fluid (virology), Neuraminidase (genetics), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (prevention & control), Reassortant Viruses (genetics), Reassortant Viruses (growth & development), Reassortant Viruses (immunology), Vaccination, Viral Plaque Assay, Viral Proteins (genetics).
- MESH :
- chemical , administration & dosage : Influenza Vaccines.
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus, Neuraminidase, Viral Proteins.
- genetics : Influenza A virus, Reassortant Viruses.
- growth & development : Influenza A virus, Reassortant Viruses.
- immunology : Influenza A virus, Influenza Vaccines, Orthomyxoviridae Infections, Reassortant Viruses.
- prevention & control : Orthomyxoviridae Infections.
- virology : Bronchoalveolar Lavage Fluid, Nasal Lavage Fluid.
- Administration, Intranasal, Animals, Cell Line, Chick Embryo, Disease Models, Animal, Dogs, Ferrets, Influenza A Virus, H1N1 Subtype, Vaccination, Viral Plaque Assay.
Abstract
Live, cold-adapted, temperature-sensitive (ca/ts) Russian influenza A vaccines are prepared in eggs by a 6:2 gene reassortment of the ca/ts donor strain A/Leningrad/134/17/57 (H2N2) (Len/17) with a current wild-type (wt) influenza A strain contributing hemagglutinin (HA) and neuraminidase (NA) genes. However, egg-derived reassortant vaccines are potentially more problematic to manufacture in large quantities than vaccines from cell-based procedures. To compare egg- and cell culture-derived reassortant vaccines, we prepared in Madin Darby canine kidney (MDCK) cells two cloned, ca/ts reassortants (25M/1, 39E/2) derived from Len/17 and a wt reference strain A/New Caledonia/20/99 (H1N1) (NC/wt). Both 25M/1 and 39E/2 reassortants preserved the ca/ts phenotype and mutations described for internal genes of the A/Len/17 parent. When compared to a commercial, egg-derived ca/ts Russian A/17/NC/99/145 (H1N1) New Caledonia vaccine (NC/145), the MDCK-derived reassortant 39E/2 vaccine conferred similar levels of protection in ferrets challenged i.n. with 7 x 10(10) pfu of NC/wt. In a dose-ranging study, the protective vaccine dose for 50% of ferrets (PD50) was less than 1.2 x 10(4) pfu for the 25M/1 vaccine derived by recombination and amplification in MDCK cells. Clonal isolates of ca/ts influenza A/New Caledonia/20/99 (H1N1) obtained by recombination and amplification entirely in MDCK cells can be highly protective i.n. vaccines.
DOI: 10.1016/j.virusres.2004.05.009
PubMed: 15351492
Affiliations:
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Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Protective efficacy of intranasal cold-adapted influenza A/New Caledonia/20/99 (H1N1) vaccines comprised of egg- or cell culture-derived reassortants.</title>
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<affiliation wicri:level="1"><nlm:affiliation>Department of Virus and Cell Biology, Vaccine and Biologics Research, Merck Research Laboratories, Merck and Co., Inc., 770 Sumneytown Pike, WP16-101, West Point, PA 19486, USA. tom_palker@merck.com</nlm:affiliation>
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<term>Animals</term>
<term>Bronchoalveolar Lavage Fluid (virology)</term>
<term>Cell Line</term>
<term>Chick Embryo</term>
<term>Disease Models, Animal</term>
<term>Dogs</term>
<term>Ferrets</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus (genetics)</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza A virus (genetics)</term>
<term>Influenza A virus (growth & development)</term>
<term>Influenza A virus (immunology)</term>
<term>Influenza Vaccines (administration & dosage)</term>
<term>Influenza Vaccines (immunology)</term>
<term>Nasal Lavage Fluid (virology)</term>
<term>Neuraminidase (genetics)</term>
<term>Orthomyxoviridae Infections (immunology)</term>
<term>Orthomyxoviridae Infections (prevention & control)</term>
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<term>Reassortant Viruses (growth & development)</term>
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<term>Chiens</term>
<term>Embryon de poulet</term>
<term>Furets</term>
<term>Glycoprotéine hémagglutinine du virus influenza (génétique)</term>
<term>Infections à Orthomyxoviridae ()</term>
<term>Infections à Orthomyxoviridae (immunologie)</term>
<term>Lignée cellulaire</term>
<term>Liquide de lavage bronchoalvéolaire (virologie)</term>
<term>Liquide de lavage nasal (virologie)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Méthode des plages virales</term>
<term>Protéines virales (génétique)</term>
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<term>Vaccins antigrippaux (immunologie)</term>
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<term>Virus de la grippe A (génétique)</term>
<term>Virus de la grippe A (immunologie)</term>
<term>Virus recombinants (croissance et développement)</term>
<term>Virus recombinants (génétique)</term>
<term>Virus recombinants (immunologie)</term>
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<term>Virus de la grippe A</term>
<term>Virus recombinants</term>
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<term>Vaccins antigrippaux</term>
<term>Virus de la grippe A</term>
<term>Virus recombinants</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term>
<term>Influenza Vaccines</term>
<term>Orthomyxoviridae Infections</term>
<term>Reassortant Viruses</term>
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<term>Animals</term>
<term>Cell Line</term>
<term>Chick Embryo</term>
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<term>Ferrets</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Vaccination</term>
<term>Viral Plaque Assay</term>
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<term>Chiens</term>
<term>Embryon de poulet</term>
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<front><div type="abstract" xml:lang="en">Live, cold-adapted, temperature-sensitive (ca/ts) Russian influenza A vaccines are prepared in eggs by a 6:2 gene reassortment of the ca/ts donor strain A/Leningrad/134/17/57 (H2N2) (Len/17) with a current wild-type (wt) influenza A strain contributing hemagglutinin (HA) and neuraminidase (NA) genes. However, egg-derived reassortant vaccines are potentially more problematic to manufacture in large quantities than vaccines from cell-based procedures. To compare egg- and cell culture-derived reassortant vaccines, we prepared in Madin Darby canine kidney (MDCK) cells two cloned, ca/ts reassortants (25M/1, 39E/2) derived from Len/17 and a wt reference strain A/New Caledonia/20/99 (H1N1) (NC/wt). Both 25M/1 and 39E/2 reassortants preserved the ca/ts phenotype and mutations described for internal genes of the A/Len/17 parent. When compared to a commercial, egg-derived ca/ts Russian A/17/NC/99/145 (H1N1) New Caledonia vaccine (NC/145), the MDCK-derived reassortant 39E/2 vaccine conferred similar levels of protection in ferrets challenged i.n. with 7 x 10(10) pfu of NC/wt. In a dose-ranging study, the protective vaccine dose for 50% of ferrets (PD50) was less than 1.2 x 10(4) pfu for the 25M/1 vaccine derived by recombination and amplification in MDCK cells. Clonal isolates of ca/ts influenza A/New Caledonia/20/99 (H1N1) obtained by recombination and amplification entirely in MDCK cells can be highly protective i.n. vaccines.</div>
</front>
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<affiliations><list><country><li>États-Unis</li>
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<tree><noCountry><name sortKey="Distefano, Daniel" sort="Distefano, Daniel" uniqKey="Distefano D" first="Daniel" last="Distefano">Daniel Distefano</name>
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<name sortKey="Kiseleva, Irina" sort="Kiseleva, Irina" uniqKey="Kiseleva I" first="Irina" last="Kiseleva">Irina Kiseleva</name>
<name sortKey="Kraiouchkine, Nikolai" sort="Kraiouchkine, Nikolai" uniqKey="Kraiouchkine N" first="Nikolai" last="Kraiouchkine">Nikolai Kraiouchkine</name>
<name sortKey="Kwan, Wan Sang" sort="Kwan, Wan Sang" uniqKey="Kwan W" first="Wan-Sang" last="Kwan">Wan-Sang Kwan</name>
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<name sortKey="Rudenko, Larisa" sort="Rudenko, Larisa" uniqKey="Rudenko L" first="Larisa" last="Rudenko">Larisa Rudenko</name>
<name sortKey="Shaw, Alan" sort="Shaw, Alan" uniqKey="Shaw A" first="Alan" last="Shaw">Alan Shaw</name>
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<name sortKey="Szymkowiak, Christopher" sort="Szymkowiak, Christopher" uniqKey="Szymkowiak C" first="Christopher" last="Szymkowiak">Christopher Szymkowiak</name>
<name sortKey="Toner, Timothy" sort="Toner, Timothy" uniqKey="Toner T" first="Timothy" last="Toner">Timothy Toner</name>
<name sortKey="Wlochowski, Joan" sort="Wlochowski, Joan" uniqKey="Wlochowski J" first="Joan" last="Wlochowski">Joan Wlochowski</name>
<name sortKey="Youil, Rima" sort="Youil, Rima" uniqKey="Youil R" first="Rima" last="Youil">Rima Youil</name>
</noCountry>
<country name="États-Unis"><noRegion><name sortKey="Palker, Thomas" sort="Palker, Thomas" uniqKey="Palker T" first="Thomas" last="Palker">Thomas Palker</name>
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